Article

Identification of BRAF V600E‑negative and MAP2K1‑posivtive mutations in an adolescent with Langerhans cell histiocytosis: a case report combined with next-generation sequencing analysis

2025-01-09

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare malignant disease with long-term multi-organ and multi-system complications that severely affects the quality of life of patients. More than 40% of LCH patients have BRAF V600E mutation and about 20-25% have MAP2K1 mutation. We report a case of localized Langerhans cell histiocytosis in an adolescent characterized by clonal aggregation of skull Langerhans cells. Thes...

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Literature Corpus work: d56672fa-a1c3-5bc8-8240-b62235f7e509
DOI: 10.22541/au.173639752.27519104/v1

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Identification of BRAF V600E‑negative and MAP2K1‑posivtive mutations in an adolescent with Langerhans cell histiocytosis: a case report combined with next-generation sequencing analysisDOI 10.22541/au.173639752.27519104/v1Read

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