Article
BRAF and MAP2K1 mutations in Langerhans cell histiocytosis: a study of 50 cases.
Human pathology - 1 Jun 2016
Alayed Khaled, Medeiros L Jeffrey, Patel Keyur P, Zuo Zhuang, Li Shaoying, Verma Shalini, Galbincea John, Cason R Craig, Luthra Rajyalakshmi, Yin C Cameron
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells, often associated with lymphocytes, eosinophils, macrophages, and giant cells. BRAF mutations, usually V600E, have been reported in 40%-70% of cases, and recently, MAP2K1 mutations have been reported in BRAF-negative cases. We assessed 50 cases of LCH for BRAF mutations and assessed a subset of cases for MAP2K1 mutations. The study group...
Topics
- Adolescent
- Adult
- Aged
- Biopsy
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Histiocytosis, Langerhans-Cell