Article
Clinical study of MAP2K1-mutated Langerhans cell histiocytosis in children.
Journal of cancer research and clinical oncology - 1 Sept 2022
Yang Ying, Wang Chanjuan, Wang Dong, Cui Lei, Li Na, Lian Hongyun, Ma Honghao, Zhao Yunze, Zhang Liping, Liu Wei, Wang Yizhuo, Wu Wanshui, Zhang Rui, Li Zhigang, Wang Tianyou
Abstract excerpt
PURPOSE: To analyze the genetic and clinical features of children with MAP2K1-mutated Langerhans cell histiocytosis (LCH). METHODS: We compared the clinical features of 37 children with MAP2K1-mutated LCH with those of the BRAFV600E mutation group (n = 133) and no known mutation group (n = 59) in...
Topics
- Child
- Histiocytosis, Langerhans-Cell
- Humans
- MAP Kinase Kinase 1
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf
- Recurrence