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BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children.

Hematological oncology - 1 Dec 2017

Zeng Kaixuan, Ohshima Koichi, Liu Yixiong, Zhang Weichen, Wang Lu, Fan Linni, Li Mingyang, Li Xia, Wang Zhe, Guo Shuangping, Yan Qingguo, Guo Ying

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a proliferative disease of CD1a+ /CD207+ dendritic cells. Recurrent BRAFV600E and MAP2K1 mutations have been reported in LCH. To investigate the relationship among the mutation, clinical findings, and differentiation status of LCH, respectively, we studied 97 cases of LCH by using Sanger sequencing and immunohistochemistry. The mutually exclusive BRAFV600E and MAP2K1...

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Identifiers

PMID: 27597420
DOI: 10.1002/hon.2344

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children.PMID 27597420Read ↗

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