Article
BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children.
Hematological oncology - 1 Dec 2017
Zeng Kaixuan, Ohshima Koichi, Liu Yixiong, Zhang Weichen, Wang Lu, Fan Linni, Li Mingyang, Li Xia, Wang Zhe, Guo Shuangping, Yan Qingguo, Guo Ying
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a proliferative disease of CD1a+ /CD207+ dendritic cells. Recurrent BRAFV600E and MAP2K1 mutations have been reported in LCH. To investigate the relationship among the mutation, clinical findings, and differentiation status of LCH, respectively, we studied 9...
Topics
- Adolescent
- Age Factors
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- MAP Kinase Kinase 1
- Male
- Mutation
- Proto-Oncogene Proteins B-raf