Article
Frequency detection of BRAF V600E mutation in a cohort of pediatric langerhans cell histiocytosis patients by next-generation sequencing.
Orphanet journal of rare diseases - 11 Jun 2021
Feng Shunqiao, Han Lin, Yue Mei, Zhong Dixiao, Cao Jing, Guo Yibing, Sun Yanling, Zhang Hao, Cao Zhenhua, Cui Xiaodai, Liu Rong
Abstract excerpt
BACKGROUND: Langerhans cell histiocytosis (LCH) is a rare neoplastic disease that occurs in both children and adults, and BRAF V600E is detected in up to 64% of the patients. Several studies have discussed the associations between BRAF V600E mutation and clinicopathological manifestations, but no...
Topics
- Adult
- Child
- Cohort Studies
- High-Throughput Nucleotide Sequencing
- Histiocytosis, Langerhans-Cell
- Humans
- Mutation
- Proto-Oncogene Proteins B-raf