Article
Frequency detection of BRAF V600E mutation in a cohort of pediatric langerhans cell histiocytosis patients by next-generation sequencing.
Orphanet journal of rare diseases - 11 Jun 2021
Feng Shunqiao, Han Lin, Yue Mei, Zhong Dixiao, Cao Jing, Guo Yibing, Sun Yanling, Zhang Hao, Cao Zhenhua, Cui Xiaodai, Liu Rong
Abstract excerpt
BACKGROUND: Langerhans cell histiocytosis (LCH) is a rare neoplastic disease that occurs in both children and adults, and BRAF V600E is detected in up to 64% of the patients. Several studies have discussed the associations between BRAF V600E mutation and clinicopathological manifestations, but no clear conclusions have been drawn regarding the clinical significance of the mutation in pediatric patients. RESULTS:...
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