Article

Old-age hippocampal sclerosis in the aged population

2018-01-01

Abstract excerpt

Old-age hippocampal sclerosis (HS), characterised by severe neuron loss in hippocampal CA1, is a poorly understood cause of dementia. At present no objective pathological HS criteria exist. In life HS is commonly diagnosed as Alzheimer's disease. HS aetiology is unclear, although it has been associated with both ischaemia and TAR-DNA-binding protein-43 (TDP-43)-related neurodegeneration. Variations in genes GRN, T...

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Literature Corpus work: d5444116-0bec-5097-9e4e-e3b609174668
DOI: 10.17863/cam.23161

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