Article
Multiple substrates of late-onset dementia: implications for brain protection.
Novartis Foundation symposium - 1 Jan 2001
Kalaria R N, Ballard C G, Ince P G, Kenny R A, McKeith I G, Morris C M, O'Brien J T, Perry E K, Perry R H, Edwardson J A
Abstract excerpt
Age is the single most important risk factor for progressive dementia in populations worldwide. In developed countries the prevalence of dementia is estimated to be 3-5% at age 65 years and expected to double every decade thereafter. Although there is ageing-related attrition of neural tissue accompanied by profound changes in brain glia, marked neuronal loss and severe cognitive impairment are associated with...
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