Article

A structure-guided approach to non-coding variant evaluation for transcription factor binding using AlphaFold 3

2025-03-20

Abstract excerpt

Non-coding single-nucleotide variants (SNVs) that alter transcription factor (TF) binding can affect gene expression and contribute to disease. Sequence-based methods can excel at predicting TF binding, but rely on training data and can exhibit TF-specific biases. Here we propose a structure-guided approach for non-coding SNVs, using AlphaFold 3 (AF3) to model TF-DNA complexes and FoldX for downstream physics-base...

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Literature Corpus work: d5422766-2848-54b2-a8d3-689c979546ac
DOI: 10.1101/2025.03.20.644433

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