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Article

Systematic analysis of binding of transcription factors to noncoding variants.

Nature - 1 Mar 2021

Yan Jian, Qiu Yunjiang, Ribeiro Dos Santos André M, Yin Yimeng, Li Yang E, Vinckier Nick, Nariai Naoki, Benaglio Paola, Raman Anugraha, Li Xiaoyu, Fan Shicai, Chiou Joshua, Chen Fulin, Frazer Kelly A, Gaulton Kyle J, Sander Maike, Taipale Jussi, Ren Bing

Abstract excerpt

Many sequence variants have been linked to complex human traits and diseases1, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have systematically assessed the binding of 270 human transcription factors to 95,886 noncoding variants in the human genome using an ultra-high-throughput multiplex protein-DNA binding assay, termed single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33505025
DOI: 10.1038/s41586-021-03211-0
PMCID: PMC9367673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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