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Article

FABIAN-variant 2026: improved prediction of the effects of DNA variants on transcription factor binding.

Nucleic acids research - 11 Jul 2026

Steinhaus Robin, Robinson Peter N, Seelow Dominik

Abstract excerpt

Variants in promoters and enhancers can alter the binding of transcription factors (TFs), but their functional assessment remains difficult. FABIAN-variant is a web application that predicts the effects of DNA variants on TF binding by comparing position weight matrix (PWM) and transcription factor flexible model (TFFM) scores between reference and variant alleles. Here, we present FABIAN-variant 2026, a major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42411323
DOI: 10.1093/nar/gkag449
PMCID: PMC13355085

Genes

TF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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