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Article

FABIAN-variant: predicting the effects of DNA variants on transcription factor binding.

Nucleic acids research - 5 Jul 2022

Steinhaus Robin, Robinson Peter N, Seelow Dominik

Abstract excerpt

While great advances in predicting the effects of coding variants have been made, the assessment of non-coding variants remains challenging. This is especially problematic for variants within promoter regions which can lead to over-expression of a gene or reduce or even abolish its expression. The binding of transcription factors to the DNA can be predicted using position weight matrices (PWMs). More recently,...

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PMID: 35639768
DOI: 10.1093/nar/gkac393
PMCID: PMC9252790

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