Article
Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.
Genome research - 1 Oct 2017
Schwessinger Ron, Suciu Maria C, McGowan Simon J, Telenius Jelena, Taylor Stephen, Higgs Doug R, Hughes Jim R
Abstract excerpt
In the era of genome-wide association studies (GWAS) and personalized medicine, predicting the impact of single nucleotide polymorphisms (SNPs) in regulatory elements is an important goal. Current approaches to determine the potential of regulatory SNPs depend on inadequate knowledge of cell-specific DNA binding motifs. Here, we present Sasquatch, a new computational approach that uses DNase footprint data to...
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