Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39

5 Feb 2025

Abstract excerpt

Regulatory T (Treg) cells are known to impede antitumor immunity, yet the regulatory mechanisms and functional roles of these cells remain poorly understood. In this study, through the characterization of multiple cancer models, we identified a substantial presence of peripherally induced Treg cells in the tumor microenvironment (TME). Depletion of these cells triggered antitumor responses and provided potent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39907686
DOI: 10.1084/jem.20240445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39PMID 39907686Read ↗

Complex Role of Regulatory T Cells (Tregs) in the Tumor Microenvironment: Their Molecular Mechanisms and Bidirectional Effects on Cancer ProgressionSemantic proximity Read ↗

CD39 <sup>+</sup> conventional CD4 <sup>+</sup> T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockadeSemantic proximity Read ↗

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes.Semantic proximity Read ↗

CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human CancerSemantic proximity Read ↗

Bystander CD4 <sup>+</sup> T cells infiltrate human tumors and are phenotypically distinctSemantic proximity Read ↗

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cellsSemantic proximity Read ↗

Bystander CD4 + T cells infiltrate human tumors and are phenotypically distinctSemantic proximity Read ↗

Reprogramming of regulatory T cells in inflammatory tumor microenvironment: can it become immunotherapy turning point?Semantic proximity Read ↗

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cellsSemantic proximity Read ↗

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells.Semantic proximity Read ↗

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer ImmunitySemantic proximity Read ↗

Role of γδ T Cells in Cancer Progression and Therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.