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Article

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes.

Cancer immunology, immunotherapy : CII - 1 May 2013

Parodi Alessia, Battaglia Florinda, Kalli Francesca, Ferrera Francesca, Conteduca Giuseppina, Tardito Samuele, Stringara Silvia, Ivaldi Federico, Negrini Simone, Borgonovo Giacomo, Simonato Alchiede, Traverso Paolo, Carmignani Giorgio, Fenoglio Daniela, Filaci Gilberto

Abstract excerpt

CD39 is an ectoenzyme, present on different immune cell subsets, which mediates immunosuppressive functions catalyzing ATP degradation. It is not known whether CD39 is expressed and implicated in the activity of CD8+ regulatory T lymphocytes (Treg). In this study, CD39 expression and function was analyzed in both CD8+ and CD4+CD25(hi) Treg from the peripheral blood of healthy donors as well as from tumor...

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Identifiers

PMID: 23359087
DOI: 10.1007/s00262-013-1392-z
PMCID: PMC11029015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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