Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

1 Jun 2018

Abstract excerpt

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients. Here, we reveal a mechanism to selectively target and reprogram the function of tumor-infiltrating Tregs (TI-Tregs) by exploiting their dependency on the histone H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29898397
DOI: 10.1016/j.celrep.2018.05.050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer ImmunityPMID 29898397Read ↗

Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapySemantic proximity Read ↗

Multiomics characteristics and immunotherapeutic potential of EZH2 in pan-cancerSemantic proximity Read ↗

Inhibition of UBE2N in regulatory T-cells boosts immunity against cancerSemantic proximity Read ↗

Complex Role of Regulatory T Cells (Tregs) in the Tumor Microenvironment: Their Molecular Mechanisms and Bidirectional Effects on Cancer ProgressionSemantic proximity Read ↗

RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunitySemantic proximity Read ↗

Reprogramming of regulatory T cells in inflammatory tumor microenvironment: can it become immunotherapy turning point?Semantic proximity Read ↗

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host diseaseSemantic proximity Read ↗

Induced regulatory T cells in inhibitory microenvironments created by cancerSemantic proximity Read ↗

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor ImmunotherapySemantic proximity Read ↗

TOX enforces the immunosuppressive program of tumor-infiltrating regulatory T cellsSemantic proximity Read ↗

Myeloid-derived suppressor cells and T regulatory cells in tumors: unraveling the dark side of the forceSemantic proximity Read ↗

EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.