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Targeting T regulatory (T reg ) cells in immunotherapy-resistant cancers

12 Jan 2024

Abstract excerpt

Primary or secondary (i.e., acquired) resistance is a common occurrence in cancer patients and is often associated with high numbers of T regulatory (Treg) cells (CD4+CD25+FOXP3+). The approval of ipilimumab and the development of similar pharmacological agents targeting cell surface proteins on Treg cells demonstrates that such intervention may overcome resistance in cancer patients. Hence, the clinical...

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PMID: 38318526
DOI: 10.20517/cdr.2023.46

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