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Article

Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease.

Journal of neurochemistry - 1 Mar 2008

Reynolds Ashley D, Glanzer Jason G, Kadiu Irena, Ricardo-Dukelow Mary, Chaudhuri Anathbandhu, Ciborowski Pawel, Cerny Ronald, Gelman Benjamin, Thomas Mark P, Mosley R Lee, Gendelman Howard E

Abstract excerpt

Microglial neuroinflammatory processes play a primary role in dopaminergic neurodegeneration for Parkinson's disease (PD). This can occur, in part, by modulation of glial function following activation by soluble or insoluble modified alpha-synuclein (alpha-syn), a chief component of Lewy bodies that is released from affected dopaminergic neurons. alpha-Syn is nitrated during oxidative stress responses and in its...

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PMID: 18036154
DOI: 10.1111/j.1471-4159.2007.05087.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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