Article

Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germ line transcription in the mouse

2018-11-21

Abstract excerpt

A deficiency in BRG1, the catalytic subunit of the SWI/SNF chromatin remodeling complex, results in a meiotic arrest during spermatogenesis. Here, we explore the causative mechanisms. BRG1 is preferentially enriched at active promoters of genes essential for spermatogonial pluripotency and meiosis. In contrast, BRG1 is also associated with the repression of somatic genes. Chromatin accessibility at these target pr...

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Literature Corpus work: d4e47951-d7b9-5a9a-8937-6e8db87d2262
DOI: 10.1101/476143

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