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ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network

3 Mar 2025

Abstract excerpt

Spermatogonial stem cells balance self-renewal with differentiation and spermatogenesis to ensure continuous sperm production. Here, we identify roles for the transcription factor zinc finger and BTB domain-containing protein 16 (ZBTB16; also known as promyelocytic leukemia zinc finger (PLZF)) in juvenile mouse undifferentiated spermatogonia (uSPG) in promoting self-renewal and cell-cycle progression to maintain...

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PMID: 40033150
DOI: 10.1038/s41594-025-01509-5

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