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Article

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2013

Smith-Roe Stephanie L, Bultman Scott J

Abstract excerpt

Mammalian SWI/SNF complexes utilize either BRG1 or BRM as alternative catalytic subunits with DNA-dependent ATPase activity to remodel chromatin. Although the two proteins are 75 % identical, broadly expressed, and have similar biochemical activities in vitro, BRG1 is essential for mouse embryonic development, while BRM is dispensable. To investigate whether BRG1 and BRM have overlapping functions during mouse...

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Identifiers

PMID: 23076393
DOI: 10.1007/s00335-012-9433-z
PMCID: PMC3562406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.PMID 23076393Read ↗

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