Article

hnRNPH1 recruits PTBP2 and SRSF3 to cooperatively modulate alternative pre-mRNA splicing in germ cells and is essential for spermatogenesis and oogenesis

2021-11-11

Abstract excerpt

<title>Abstract</title> <p>Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell development. However, the molecular mechanism underlying that control alternative mRNA expression during germ cell development remains poorly understood. Herein, we showed that hnRNPH1, an RNA-binding protein, is highly expressed in the reproductive system and localized in the chromosomes of meiotic cells...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ce21244-7f32-5ba1-adf1-77f0757965d0
DOI: 10.21203/rs.3.rs-1060705/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

hnRNPH1 recruits PTBP2 and SRSF3 to cooperatively modulate alternative pre-mRNA splicing in germ cells and is essential for spermatogenesis and oogenesisDOI 10.21203/rs.3.rs-1060705/v1Read

HnRNPK is essential for Sertoli cells development and male fertility in miceSemantic proximity Read

Azoospermia phenotype and scRNA-seq reveal hnRNPK as a factor essential for male germ cell development in mice.Semantic proximity Read

PA1 Participates in the Maintenance of Blood-Testis Barrier Integrity via Cooperation with JUN in the Sertoli Cells of Mice.Semantic proximity Read

Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesisSemantic proximity Read

Dissecting Human Gonadal Cell Lineage Specification and Sex Determination Using a Single-Cell RNA-Seq ApproachSemantic proximity Read

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicingSemantic proximity Read

Novel Gene Regulation in Normal and Abnormal SpermatogenesisSemantic proximity Read

Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germlineSemantic proximity Read

Genomic landscape of developing male germ cellsSemantic proximity Read

Genes Regulating Spermatogenesis and Sperm Function Associated With Rare DisordersSemantic proximity Read

Transcription and post-transcriptional regulation of spermatogenesisSemantic proximity Read

PA1 participates in the maintenance of blood–testis barrier integrity via cooperation with JUN in the Sertoli cells of miceSemantic proximity Read