Article

POU4F2/Brn-3b is Essential for Spermatogenesis and its Disruption is Linked to Male Infertility in Mice and Humans

2025-10-31

Abstract excerpt

<title>Abstract</title> <p> Male infertility is rising globally, yet its causes remain unclear. This study identifies the transcription factor Brn-3b (POU4F2) as essential for spermatogenesis and sperm function. Brn-3b is highly expressed in mature spermatids and infertility in constitutive male Brn-3b knockout (KO) mice is characterised by structural and functional testicular changes such as reduced sperm count...

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Literature Corpus work: fa528ff5-28c7-5986-96fa-3168f60bf76b
DOI: 10.21203/rs.3.rs-7446280/v1

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