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SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis

19 Oct 2022

Abstract excerpt

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive transcriptome misregulation, including a failure to eliminate meiotically expressed transcripts in early haploid cells, and accumulation of...

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PMID: 36259644
DOI: 10.1093/nar/gkac900

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