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Article

DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

1 Sept 2016

Abstract excerpt

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator of male sexual differentiation. Here we investigate the role of Dmrt1 in mouse spermatogonial stem cell (SSC)...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 27583450
DOI: 10.1371/journal.pgen.1006293

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