Article
Cancer stem cells: targeting tumors at the source.
European review for medical and pharmacological sciences - 1 May 2015
Zhang P-Y, Yang Y-J, Xue Y, Fu J, Zhang C-X, Wang Y, Yang Y, Shi H
Abstract excerpt
The cancer stem cell hypothesis states that tumors rely exclusively on the continued proliferation of a subset of cancer cells that originated from normal adult stem cells. These cells have two key traits: multipotency, and self-renewal. The prolonged lifespan of stem cells makes them perfect candidates for the accumulation of carcinogenic mutations that would convert them into cancer stem cells (CSCs) no longer...
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