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A model for the intrinsic limit of cancer therapy: Duality of treatment-induced cell death and treatment-induced stemness

25 Jul 2022

Abstract excerpt

Intratumor cellular heterogeneity and non-genetic cell plasticity in tumors pose a recently recognized challenge to cancer treatment. Because of the dispersion of initial cell states within a clonal tumor cell population, a perturbation imparted by a cytocidal drug only kills a fraction of cells. Due to dynamic instability of cellular states the cells not killed are pushed by the treatment into a variety of...

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PMID: 35877695
DOI: 10.1371/journal.pcbi.1010319

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