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CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction

2023-02-27

Abstract excerpt

<title>Abstract</title> <p>Intra-tumour heterogeneity provides the fuel for the evolution and selection of subclonal tumour cell populations. However, accurate inference of tumour subclonal architecture and reconstruction of tumour evolutionary history from bulk DNA sequencing data remains challenging. Sequencing and alignment artefacts cannot be distinguished from real cancer somatic mutations and errors in the...

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Literature Corpus work: 30cd8be2-ad5c-5aab-a86d-394006e316e9
DOI: 10.21203/rs.3.pex-2158/v1

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