Article
Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.
International journal of radiation oncology, biology, physics - 15 Mar 2018
Rahal Omar M, Wolfe Adam R, Mandal Pijus K, Larson Richard, Tin Sanda, Jimenez Cristina, Zhang Dadong, Horton Janet, Reuben James M, McMurray John S, Woodward Wendy A
Abstract excerpt
PURPOSE: To determine the role of macrophage polarization on the response of inflammatory breast cancer (IBC) cells to radiation and whether modulation of macrophage plasticity can alter radiation response. METHODS AND MATERIALS: The human THP-1 monocyte cell line and primary human monocytes isolated from peripheral blood mononuclear cells were differentiated into macrophages and polarized to either an...
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