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Matairesinol repolarizes M2 macrophages to M1 phenotype to induce apoptosis in triple-negative breast cancer cells.

Immunopharmacology and immunotoxicology - 1 Feb 2025

Chaudhary Amol, Patil Prajakta, Raina Prerna, Kaul-Ghanekar Ruchika

Abstract excerpt

OBJECTIVE: Triple-Negative Breast Cancer (TNBC), the most challenging subtype of Breast Cancer (BC), currently lacks targeted therapy, presenting a significant therapeutic gap in its management. Tumor Associated Macrophages (TAMs) play a significant role in TNBC progression and could be targeted by repolarizing them from M2 to M1 phenotype. Matairesinol (MAT), a plant lignan, has been shown to exhibit anticancer,...

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Identifiers

PMID: 39722605
DOI: 10.1080/08923973.2024.2425028

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