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Tumor-associated macrophages of the M1/M2 phenotype are involved in the regulation of malignant biological behavior of breast cancer cells through the EMT pathway.

Medical oncology (Northwood, London, England) - 16 May 2022

Chen Zhuo, Wu Jing, Wang Liang, Zhao Hua, He Jie

Abstract excerpt

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. More and more studies have shown that the tumor immune microenvironment (TME) of TNBC is closely related to its poor prognosis and early metastasis. We try to explain how tumor-associate macrophages (TAMs), an important component of the TME, function in the matrix of TNBC. Therefore, we induced THP-1 cells to become M1-TAMs and...

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PMID: 35570226
DOI: 10.1007/s12032-022-01670-7

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