Article
Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.
Genome biology - 29 Jun 2020
Do Catherine, Dumont Emmanuel L P, Salas Martha, Castano Angelica, Mujahed Huthayfa, Maldonado Leonel, Singh Arunjot, DaSilva-Arnold Sonia C, Bhagat Govind, Lehman Soren, Christiano Angela M, Madhavan Subha, Nagy Peter L, Green Peter H R, Feinman Rena, Trimble Cornelia, Illsley Nicholas P, Marder Karen, Honig Lawrence, Monk Catherine, Goy Andre, Chow Kar, Goldlust Samuel, Kaptain George, Siegel David, Tycko Benjamin
Abstract excerpt
BACKGROUND: Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cells, remain to be clarified. RESULTS: We perform whole genome methyl-seq on diverse normal cells and tissues and three cancer types. After excluding imprinting, the data...
Topics
Join the communities discussing this publication.