Article
Development of a method for identifying and functionally analyzing allele-specific DNA methylation based on BS-seq data.
Epigenomics - 1 Nov 2019
Zhu Jiang, Su Mu, Gu Yue, Zhang Xingda, Lv Wenhua, Zhang Shumei, Sun Zhongyi, Lu Haibo, Zhang Yan
Abstract excerpt
Aim: To comprehensively identify allele-specific DNA methylation (ASM) at the genome-wide level. Methods: Here, we propose a new method, called GeneASM, to identify ASM using high-throughput bisulfite sequencing data in the absence of haplotype information. Results: A total of 2194 allele-specific DNA methylated genes were identified in the GM12878 lymphocyte lineage using GeneASM. These genes are mainly enriched...
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