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Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy

3 Dec 2020

Abstract excerpt

Abstract Most human cancers converge to a deregulated methylome with reduced global levels and elevated methylation at select CpG islands. To investigate the emergence and dynamics of the cancer methylome, we characterized genome-wide DNA methylation in preneoplastic monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), including serial samples collected across disease course. We detected...

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PMID: 33604581
DOI: 10.1158/2643-3230.bcd-19-0058

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