Article

Continuous DNA Methylation Deconvolution-Based Surrogate for B-Cell Differentiation State in CLL

2025-09-16

Abstract excerpt

Chronic Lymphocytic Leukemia (CLL) is clinically divided into IGHV mutated (M-CLL) and IGHV unmutated (U-CLL) subtypes, which are thought to arise from distinct cells of origin along the B-cell differentiation pathway. We measured genome-scale DNA methylation in purified CLL samples ( n = 89 ) and utilized reference-based cell deconvolution techniques to develop a continuous metric of epigenetic similarity acr...

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Literature Corpus work: 52fe0782-80f2-55f7-ba22-af7389d46cab
DOI: 10.1101/2025.09.16.676535

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