Article
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
Nature genetics - 1 Nov 2015
Kretzmer Helene, Bernhart Stephan H, Wang Wei, Haake Andrea, Weniger Marc A, Bergmann Anke K, Betts Matthew J, Carrillo-de-Santa-Pau Enrique, Doose Gero, Gutwein Jana, Richter Julia, Hovestadt Volker, Huang Bingding, Rico Daniel, Jühling Frank, Kolarova Julia, Lu Qianhao, Otto Christian, Wagener Rabea, Arnolds Judith, Burkhardt Birgit, Claviez Alexander, Drexler Hans G, Eberth Sonja, Eils Roland, Flicek Paul, Haas Siegfried, Humme Michael, Karsch Dennis, Kerstens Hinrik H D, Klapper Wolfram, Kreuz Markus, Lawerenz Chris, Lenzek Dido, Loeffler Markus, López Cristina, MacLeod Roderick A F, Martens Joost H A, Kulis Marta, Martín-Subero José Ignacio, Möller Peter, Nage Inga, Picelli Simone, Vater Inga, Rohde Marius, Rosenstiel Philip, Rosolowski Maciej, Russell Robert B, Schilhabel Markus, Schlesner Matthias, Stadler Peter F, Szczepanowski Monika, Trümper Lorenz, Stunnenberg Hendrik G, Küppers Ralf, Ammerpohl Ole, Lichter Peter, Siebert Reiner, Hoffmann Steve, Radlwimmer Bernhard
Abstract excerpt
Although Burkitt lymphomas and follicular lymphomas both have features of germinal center B cells, they are biologically and clinically quite distinct. Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples. Comparison of Burkitt and...
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