Article

Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier

2025-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Barriers of the central nervous system (CNS), such as the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), regulate the two-way exchange of material between the blood and CNS. These barriers pose a considerable challenge for efficacious delivery of intravenously administered therapies into the CNS, motivating exploration of their function and ways to modulate their proper...

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Literature Corpus work: d489fbb1-339d-5167-88da-f3954668667a
DOI: 10.1101/2025.03.14.642142

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