Exofection as a Therapeutic Modality: Restoring P-gp Activity via Trophoblast-Derived EV in Neuroinflammatory Disorders

Abstract excerpt

<h4>Background</h4> P-glycoprotein (P-gp/ABCB1) is a key efflux transporter that maintains barrier integrity by clearing xenobiotics and toxic metabolites. At the feto-maternal interface, trophoblast-derived extracellular vesicles (CTC-EVs) naturally and transiently transfer functional P-gp to maternal decidual cells, restoring lost and or reduced P-gp function (exofection) to sustain pregnancy homeostasis. A sim...

Topics

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• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Blood-Brain Barrier
• Cell Differentiation
• Extracellular vesicles in disease
• Pregnancy and preeclampsia studies
• Preterm Birth and Chorioamnionitis
• Reproductive System and Pregnancy

Identifiers and source

Literature Corpus work

3c3d9e6f-d55c-5546-b1ce-12d57521e0bb

DOI

10.64898/2026.04.02.716001