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Article

Delivery of small-interfering RNA (siRNA) to the brain

1 Feb 2009

Abstract excerpt

BACKGROUND: Two fundamental difficulties in the delivery of drugs to treat central nervous system (CNS) diseases are the systemic delivery of therapeutics across the bloodbrain-barrier (BBB), and the targeting of drugs to specific tissues or cells within the brain. With the advent and promise of RNA-based therapeutics that utilize RNA interference (RNAi) to trigger specific silencing of genes within diseased...

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PMID: 19441914
DOI: 10.1517/13543770802680195

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