Article

Cracking the Blood–Brain Barrier Code: Rational Nanomaterial Design for Next-Generation Neurological Therapies

2025-07-08

Abstract excerpt

This review establishes a robust conceptual and mechanistic framework for rationally designing advanced nanobiotechnological systems explicitly tailored for efficient blood–brain barrier (BBB) translocation, addressing one of the most critical challenges in neurological drug delivery. We systematically dissect the mechanisms governing nanoparticle (NP)-BBB interactions, focusing on receptor-mediated transcytosis,...

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Literature Corpus work: 7a79365e-fb88-5ecf-8573-44123752615f
DOI: 10.20944/preprints202507.0667.v1

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