Article

Berberine-inspired ionizable lipid for self-structure stabilization and potent brain targeting delivery of nucleic acid therapeutics

2024-07-10

Abstract excerpt

<title>Abstract</title> Despite advancements in targeting organs such as the liver, spleen, and lungs with lipid nanoparticles (LNPs), the challenge of traversing the blood-brain barrier (BBB) significantly impedes the progress of gene therapies for neurological disorders. Motivated by the structural and functional characteristics of alkaloids, we developed a novel library of ionizable lipid molecules based on...

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Literature Corpus work: 1160e603-562f-5166-8564-2f325435c24e
DOI: 10.21203/rs.3.rs-4626003/v1

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