Article

Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer

2018-12-27

Abstract excerpt

<h4>INTRODUCTORY PARAGRAPH</h4> Deciphering principles of inter-individual tumor heterogeneity is essential for refinement of personalized anti-cancer therapy. Unlike cancers of adulthood, pediatric malignancies including Ewing sarcoma (EwS) feature a striking paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here we demonstrate in t...

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Literature Corpus work: d4859dac-4119-5466-b46c-ca73d172105c
DOI: 10.1101/506659

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