Article

Germline predisposition to pediatric Ewing sarcoma is uniquely characterized by inherited pathogenic variants in DNA damage repair genes

2022-01-11

Abstract excerpt

More knowledge is needed around the role and importance of specific genes in germline predisposition to Ewing sarcoma to inform biological investigation and clinical practice. In this study, we evaluated the enrichment of pathogenic germline variants in Ewing sarcoma relative to other pediatric sarcoma subtypes, as well as patterns of inheritance of these variants. We carried out an ancestry-matched case-control a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6046a370-f4e9-58f3-b7f0-35fcb605ec26
DOI: 10.1101/2022.01.07.22268685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germline predisposition to pediatric Ewing sarcoma is uniquely characterized by inherited pathogenic variants in DNA damage repair genesDOI 10.1101/2022.01.07.22268685Read

Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes.Semantic proximity Read

Germline Variation and Somatic Alterations in Ewing Sarcoma.Semantic proximity Read

Prevalence and clinical implications of germline pathogenic variants in cancer predisposing genes in young patients across sarcoma subtypes.Semantic proximity Read

Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of riskSemantic proximity Read

Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.Semantic proximity Read

Identification of germline cancer predisposition variants in pediatric sarcoma patients from somatic tumor testing.Semantic proximity Read

Genetic Predisposition to Solid Pediatric CancersSemantic proximity Read

Monogenic and polygenic determinants of sarcoma risk: an international genetic study.Semantic proximity Read

Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma.Semantic proximity Read

Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas.Semantic proximity Read

Simultaneous Occurrence of Multiple Neoplasms in Children with Cancer Predisposition Syndromes: Collaborating with Abnormal GenesSemantic proximity Read

Genetic susceptibility in children, adolescents, and young adults diagnosed with soft-tissue sarcomas.Semantic proximity Read