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Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk

2026-02-09

Abstract excerpt

Ewing sarcoma (EwS) is a rare, aggressive pediatric malignancy driven by FET :: ETS family fusions ( EWSR1 :: FLI1 in >85% of cases) with no established environmental risk factors. To investigate germline predisposition, we analyzed 2,014 EwS cases and 10,525 cancer-free controls in a two-stage analysis that combined an international genome-wide association study and a case□parent trio study. The combined meta...

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Literature Corpus work
79edbdc0-9d8f-5e1b-bd8f-101c48c2b573
DOI
10.64898/2026.02.06.26345779
Open publication

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Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of riskDOI 10.64898/2026.02.06.26345779
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