Article
Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers
2019-11-15
Abstract excerpt
Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here we developed a computational framework to identify risk noncoding mutations of all classes by joint analysis of mutation and gene expression data. We identified thousands of SNVs/small indels and structural variants as candidate risk mutations in five major pediatric cancers. We experimentally validated the oncogenic...
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Identifiers and source
- Literature Corpus work
- 186049bd-930b-5764-a27d-78a693130a16
- DOI
- 10.1101/843102