Article
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.
Nature genetics - 1 Sept 2015
Grünewald Thomas G P, Bernard Virginie, Gilardi-Hebenstreit Pascale, Raynal Virginie, Surdez Didier, Aynaud Marie-Ming, Mirabeau Olivier, Cidre-Aranaz Florencia, Tirode Franck, Zaidi Sakina, Perot Gaëlle, Jonker Anneliene H, Lucchesi Carlo, Le Deley Marie-Cécile, Oberlin Odile, Marec-Bérard Perrine, Véron Amélie S, Reynaud Stephanie, Lapouble Eve, Boeva Valentina, Rio Frio Thomas, Alonso Javier, Bhatia Smita, Pierron Gaëlle, Cancel-Tassin Geraldine, Cussenot Olivier, Cox David G, Morton Lindsay M, Machiela Mitchell J, Chanock Stephen J, Charnay Patrick, Delattre Olivier
Abstract excerpt
Deciphering the ways in which somatic mutations and germline susceptibility variants cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions between EWSR1 and members of the ETS gene family, usually EWSR1-FLI1, leading to the generation of oncogenic transcription factors that bind DNA at GGAA motifs. A recent genome-wide association study identified susceptibility variants near EGR2....
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