Article
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.
Nature communications - 9 Aug 2018
Machiela Mitchell J, Grünewald Thomas G P, Surdez Didier, Reynaud Stephanie, Mirabeau Olivier, Karlins Eric, Rubio Rebeca Alba, Zaidi Sakina, Grossetete-Lalami Sandrine, Ballet Stelly, Lapouble Eve, Laurence Valérie, Michon Jean, Pierron Gaelle, Kovar Heinrich, Gaspar Nathalie, Kontny Udo, González-Neira Anna, Picci Piero, Alonso Javier, Patino-Garcia Ana, Corradini Nadège, Bérard Perrine Marec, Freedman Neal D, Rothman Nathaniel, Dagnall Casey L, Burdett Laurie, Jones Kristine, Manning Michelle, Wyatt Kathleen, Zhou Weiyin, Yeager Meredith, Cox David G, Hoover Robert N, Khan Javed, Armstrong Gregory T, Leisenring Wendy M, Bhatia Smita, Robison Leslie L, Kulozik Andreas E, Kriebel Jennifer, Meitinger Thomas, Metzler Markus, Hartmann Wolfgang, Strauch Konstantin, Kirchner Thomas, Dirksen Uta, Morton Lindsay M, Mirabello Lisa, Tucker Margaret A, Tirode Franck, Chanock Stephen J, Delattre Olivier
Abstract excerpt
Ewing sarcoma (EWS) is a pediatric cancer characterized by the EWSR1-FLI1 fusion. We performed a genome-wide association study of 733 EWS cases and 1346 unaffected individuals of European ancestry. Our study replicates previously reported susceptibility loci at 1p36.22, 10q21.3 and 15q15.1, and identifies new loci at 6p25.1, 20p11.22 and 20p11.23. Effect estimates exhibit odds ratios in excess of 1.7, which is...
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