Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

11 Sept 2019

Abstract excerpt

Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here, we demonstrate in EwS how cooperation of dominant oncogenes and regulatory germline variants determine tumor growth, patient survival and drug response. Binding of the oncogenic EWSR1-FLI1 fusion transcription factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to RNA modifications and cancer
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31511524
DOI: 10.1038/s41467-019-12071-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomesPMID 31511524Read ↗

Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancerSemantic proximity Read ↗

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationSemantic proximity Read ↗

Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of riskSemantic proximity Read ↗

Non-coding mutations reveal cancer driver cistromes in luminal breast cancerSemantic proximity Read ↗

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcomaSemantic proximity Read ↗

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.Semantic proximity Read ↗

Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes.Semantic proximity Read ↗

Germline predisposition to pediatric Ewing sarcoma is uniquely characterized by inherited pathogenic variants in DNA damage repair genesSemantic proximity Read ↗

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.Semantic proximity Read ↗

Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer.Semantic proximity Read ↗

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancersSemantic proximity Read ↗

Genomic landscape of Ewing sarcoma: a pooled analysis of 538 cases and clinicopathological correlationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.