Article

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

2022-09-03

Abstract excerpt

The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus. Some reports have led to annotation of both Orf3a proteins as a viroporin. Here we show that neither SARS-CoV-2 nor SARS-CoV-1 form functional ion conducting pores and that the conductances measured are common con...

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Literature Corpus work: 625ce935-13ce-5599-bb5d-5b4dd774621a
DOI: 10.1101/2022.09.02.506428

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