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Article

Unification and extensive diversification of M/Orf3-related ion channel proteins in coronaviruses and other nidoviruses

1 Jan 2021

Abstract excerpt

The coronavirus, Severe Acute Respiratory Syndrome (SARS)-CoV-2, responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic, has emphasized the need for a better understanding of the evolution of virus-host interactions. ORF3a in both SARS-CoV-1 and SARS-CoV-2 are ion channels (viroporins) implicated in virion assembly and membrane budding. Using sensitive profile-based homology detection methods,...

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PMID: 33692906
DOI: 10.1093/ve/veab014

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