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Article

Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern.

The Journal of general virology - 1 Aug 2025

Breitinger Ulrike, Zakaria Zeina Ihab Seifeldin, Mahgoub Haya Alaa, Wiessler Anna-Lena, Tuerker Esra, Villmann Carmen, Breitinger Hans-Georg

Abstract excerpt

Infection with SARS-CoV-2 continues to be a threat to human health. Despite successful immunization campaigns, effective treatment of COVID-19 remains an essential need to help patients and prevent the spread of new virus strains. Viroporins are intracellular ion channels that are essential for virus replication and release, thus presenting promising pharmaceutical targets. Mutations found in variants of concern...

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PMID: 40768270
DOI: 10.1099/jgv.0.002135
PMCID: PMC12328068

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